Natural and targeted circuit reorganization after spinal cord injury
| Résumé | A spinal cord injury disrupts communication between the brain and the circuits in the spinal cord that regulate neurological functions. The consequences are permanent paralysis, loss of sensation and debilitating dysautonomia. However, the majority of circuits located above and below the injury remain anatomically intact, and these circuits can reorganize naturally to improve function. In addition, various neuromodulation therapies have tapped into these processes to further augment recovery. Emerging research is illuminating the requirements to reconstitute damaged circuits. Here, we summarize these natural and targeted reorganizations of circuits after a spinal cord injury. We also advocate for new concepts of reorganizing circuits informed by multi-omic single-cell atlases of recovery from injury. These atlases will uncover the molecular logic that governs the selection of ‘recovery-organizing’ neuronal subpopulations, and are poised to herald a new era in spinal cord medicine. |
| Auteurs | Mark A. Anderson, Jordan W. Squair, Matthieu Gautier,Thomas H. Hutson, Claudia Kathe, Quentin Barraud, Jocelyne Bloch and Grégoire Courtine |
| Titre de revue/journal, volume et numéro | Nature Neuroscience, volume 25. |
| Langue de la publication et/ou de traduction | Anglais (langue d’origine) |
| Année de parution | 2022 |
| Pays | Suisse |
| Institutions affiliées | Institut NeuroX, Institut fédéral de la technologie de Suisse et Université de Lausanne. |
| Lien vers la publication | https://doi.org/10.1038/s41593-022-01196-1 |
| Type d’accès à la publication | Gratuit (résumé seulement) |
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